From place-based English elements Knox + son; effectively 'son of the knoll/hill,' a locational surname form.
Knoxton is a rare and striking surname-style name built on the Scottish and Northern English topographic root 'cnoc' (pronounced 'knock'), a Gaelic word meaning a rounded hill or hillock. This root appears throughout Celtic place-names from Scotland to Ireland, embedded in dozens of villages and landmarks that shaped the surnames of families who lived near such geographical features. The more familiar Knox — borne by the 16th-century Scottish reformer John Knox, whose thundering religious influence reshaped the Presbyterian church — derives from the same foundation, and Knoxton can be understood as an elaborated, place-name form: essentially 'the settlement on the hill.'
John Knox himself, despite — or perhaps because of — his fierce and uncompromising character, gave the Knox root a particular energy in Scottish cultural memory. His name became associated with principled defiance and a willingness to confront established power, qualities that have made Knox a quietly popular given name in American naming culture, particularly in the South. Knoxton extends that surname tradition with a grander, more place-name-like fullness, following the contemporary fashion for names that sound like lost English estates or frontier townships.
As a given name, Knoxton sits at the very edge of modern invented naming — it has the ring of a genuine historical surname but is vanishingly rare as a first name, giving it an air of singular distinction. Parents choosing it are typically drawn to strong consonant-heavy names with tangible geographic roots, seeking something that sounds established and serious rather than whimsical. It fits naturally alongside names like Braxton, Paxton, and Weston, yet carries a distinctive Scottish inflection all its own.