Rare diminutive, possibly from Ambrose (Greek "immortal") or Amaziah (Hebrew "strength of God").
Amzie is a rare and warmly eccentric name whose precise origins are somewhat elusive, which is itself part of its appeal. It most likely developed as an Americanized pet form of Amasa, a Hebrew name meaning burden-bearer, carried by a military commander in the court of King David as described in the Second Book of Samuel. In the nineteenth-century American South and Midwest, Amasa circulated as a given name — it was one of the middle names of James A.
Garfield, the twentieth president — and Amzie likely emerged as an affectionate domestic diminutive of that more formal name. Alternately, some name historians connect Amzie to Ambrose, via a compressed phonetic path: Ambrose to Ambrozie to Amzie. Ambrose itself traces to the Greek Ambrosios, meaning immortal or divine — a name made famous by Saint Ambrose of Milan, the fourth-century bishop who baptized Augustine and helped shape Western Christianity.
Either genealogy gives Amzie a more impressive lineage than its homespun sound might initially suggest. Amzie is particularly associated with Amzie Moore, the Mississippi civil rights leader whose Delta farm became a gathering point for activists in the 1950s and '60s. Bob Moses credited Moore with inspiring the voter registration drives that became central to the movement.
That association gives the name a quiet gravity — a reminder that unusual, regional names can belong to people of profound historical consequence. For parents drawn to names that are genuinely uncommon without being invented, Amzie occupies a singular niche.