From Greek 'Alexandros' meaning 'defender of the people,' via Spanish/Italian form.
Alexandro is the Latinate and Hispanic variant of Alexander, one of the most consequential names in world history, derived from the ancient Greek Alexandros — a compound of alexein ("to defend," "to protect") and anēr/andros ("man"), yielding the meaning "defender of men" or "protector of mankind." The name was carried to immortality by Alexander the Great of Macedon (356–323 BCE), who by the age of thirty had conquered an empire stretching from Greece to northwestern India and seeded the Hellenistic world with Greek culture, language, and cities bearing his name. That single historical figure made Alexandros one of the most replicated names across languages and centuries: Alexander in English, Alexandre in French and Portuguese, Alessandro in Italian, Iskander in Arabic and Persian, Aleksander in Slavic languages.
Alexandro represents the form that took root in Spanish-speaking cultures, carrying the full weight of that classical inheritance while wearing the warm vowel endings of the Romance world. Across Latin America and Spain, Alexandro and its close variant Alejandro have long been common names for boys, associated with strength, leadership, and a certain aristocratic bearing. Alejandro gained global pop-cultural resonance through Lady Gaga's 2010 song of the same name, which brought the sound to audiences worldwide.
The form Alexandro retains a slightly more formal, classical feel than Alejandro — closer to the Latin root, as though the Renaissance humanists had directly Latinized the Greek original. It is a name of unmistakable gravity and history, worn lightly in everyday life but vast in its echoes.